High-Performance Protein Structure Comparison
نویسندگان
چکیده
Comparing proteins structures is important for protein classification and for understanding the protein functions. We have developed a method PROuST [3] for protein structure comparison. PROuST consists of two main components: the first generates hypotheses of similarity for a target protein using an index-based search, while the second verifies these hypotheses by performing pairwise alignments by dynamic programming (DP). Since this method is both compute and data intensive, we experiment with the emerging grid technology [4]. Grid is becoming an unavoidable aspect for the solution of both compute and data intensive problems. The computational grid enables the use of a large number of different machines acting as a single one, by sharing both storage capacity and computing power. This presentation focuses on the application that implements PROuST on a grid and deals with the issues of data management and algorithmic enhancement for an efficient porting of the application onto the grid.
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تاریخ انتشار 2006